Coulombe’s NSF project aims to understand the onset of atrial arrhythmias in non-inherited Wolff-Parkinson White (WPW) syndrome. Her team will develop cardiovascular tissue in a dish using patient-derived human induced pluripotent stem cells through a collaboration with RI Hospital. The vast majority of WPW patients lack an inherited genetic mutation; the in vitro cardiac models will help identify biomechanical and biochemical stressors that contribute to atrial arrhythmia. Full story here.